CardiotoxicCompounds
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CardiotoxicCompounds
Gold Standard Cardiotoxic Compounds
The Gold Compound working group has accepted 7 and rejected 6 out of a total of 13 cardiotoxic compounds, based on Selection Criteria defined by the Gold Compound Working Group.
Accepted
Compound | Image | Target | Toxicities |
---|---|---|---|
Carbachol | Cholinergic (parasympathomimetic) agent | ||
Dimethoxy-naphthoquinone (DMNQ) | MOA standard for redox cycling | Cytotoxicity | |
Doxorubicin | DNA oxidation | Cytotoxicity | |
E-4031 | Class III antiarrhythmic potassium channel blocker | Cardiac arrhythmias | |
Iodoacetamide | MOA standard for thiol alkylation | Cytotoxicity | |
Methotrexate | Dihydrofolate reductase (DHFR) inhibition | Fibrosis | |
Rotenone | complex I/ubiquinone | Cytotoxicity |