CardiotoxicCompounds

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CardiotoxicCompounds
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Gold Standard Cardiotoxic Compounds

The Gold Compound working group has accepted 7 and rejected 6 out of a total of 13 cardiotoxic compounds, based on Selection Criteria defined by the Gold Compound Working Group.

Accepted

Compound Image Target Toxicities
Carbachol Carbachol.png Cholinergic (parasympathomimetic) agent
Dimethoxy-naphthoquinone (DMNQ) DMNQ.png MOA standard for redox cycling Cytotoxicity
Doxorubicin Doxorubicin.png DNA oxidation Cytotoxicity
E-4031 E-4031.png Class III antiarrhythmic potassium channel blocker Cardiac arrhythmias
Iodoacetamide Iodoacetamide.png MOA standard for thiol alkylation Cytotoxicity
Methotrexate Methotrexate.png Dihydrofolate reductase (DHFR) inhibition Fibrosis
Rotenone Rotenone.png complex I/ubiquinone Cytotoxicity


Authors of this ToxBank wiki page

David Bower, Egon Willighagen
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