Executive Summary Information
|Mechanisms||Carbon tetrachloride is oxidized to the trichloromethyl free radical, from which ensues alkylation of proteins and DNA along with lipid peroxidation. Depletion of ATP precedes acute cytotoxicity. Carcinogenicity is observed on long-term, low dose exposure.|
|Comments||This compound was selected to exemplify free radical-based chemical reactivity and has secondary utility as a standard for steatosis and fibrosis. Acute toxicity due to a solvent effect on cellular membranes can complicate toxicity profiling, especially at concentrations above 0.5 mM.|
|Feedback Contact||Gold Compound Working Group (GCWG)|
|Target||MOA standard for free radical generation|
The following resource link will perform a PubMed query for the terms "carbon tetrachloride" and "liver toxicity".
Carbon tetrachloride Search
The recommended source is Sigma Aldrich, product number 02671.
|Tetrachloromethane (carbon tetrachloride)|
|Storage||Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Store in cool place.|
|Stability||Limited shelf life, expiry date on the label|