From ToxBankWiki

Jump to: navigation, search

Gold Standard Hepatotoxic Compounds

The Gold Compound working group has accepted 20 and rejected 16 out of a total of 36 hepatotoxic compounds, based on Selection Criteria defined by the Gold Compound Working Group.


Compound Image Target Toxicities
Acetaminophen Acetaminophen.png COX-2c Cytotoxicity
Aflatoxin B1 Aflatoxin B1.png possibly DNA binding Apoptosis
Allyl alcohol Allylalcohol.png Cytotoxicity,Fibrosis
Amiodarone Amiodarone.png beta blocker, K channel blocker Cytotoxicity,Phospholipidosis,Steatosis
Beta-Naphthoflavone Beta-napthoflavone.png
Bosentan Bosentan.png endothelin receptor antagonist Cholestasis
CCl4 Tetrachloromethane.png MOA standard for free radical generation Cytotoxicity,Steatosis
Chlorpromazine Chlorpromazine.png dopamine, serotonin, adrenergic, histamine receptors Cholestasis,Cytotoxicity
Dimethoxy-naphthoquinone (DMNQ) DMNQ.png MOA standard for redox cycling Cytotoxicity
Dirlotapide Dirlotapide.png MTTP inhibitor Steatosis
FCCP FCCP.png Cytotoxicity
Fluoxetine Fluoxetine.png Selective serotinin reuptake inhibitor (SSRI),NMDA receptors containing the GluN2B Phospholipidosis
Iodoacetamide Iodoacetamide.png MOA standard for thiol alkylation Cytotoxicity
Methotrexate Methotrexate.png Dihydrofolate reductase (DHFR) inhibition Fibrosis
Oligomycin A Oligomycin.png
Rifampicin Rifampicin.png PXR receptor Steatosis
Rotenone Rotenone.png complex I/ubiquinone Cytotoxicity
TO901317 TO901317.png
Tamoxifen Tamoxifen.png estrogen receptor Cholestasis,Epigenetics,Steatosis
Valproic Acid Valproic acid.png GABA transaminase Cytotoxicity

Authors of this ToxBank wiki page

David Bower, Egon Willighagen, Matthew Clark
Personal tools
Renal Toxins
Special Substances
Undifferentiated Stem Cells
hiPSC Lines
Liver Cell Lines
iPS-derived Cardiomyocytes
Reagents (Growth Factors)
Reagents (Antibodies)
Reagents (Others)
Suppliers (Cells)