HepatotoxicCompounds
From ToxBankWiki
HepatotoxicCompounds
Gold Standard Hepatotoxic Compounds
The Gold Compound working group has accepted 20 and rejected 16 out of a total of 36 hepatotoxic compounds, based on Selection Criteria defined by the Gold Compound Working Group.
Accepted
| Compound | Image | Target | Toxicities |
|---|---|---|---|
| Acetaminophen |  | COX-2c | Cytotoxicity |
| Aflatoxin B1 |  | possibly DNA binding | Apoptosis |
| Allyl alcohol |  | Cytotoxicity,Fibrosis | |
| Amiodarone |  | beta blocker, K channel blocker | Cytotoxicity,Phospholipidosis,Steatosis |
| Beta-Naphthoflavone |  | ||
| Bosentan |  | endothelin receptor antagonist | Cholestasis |
| CCl4 |  | MOA standard for free radical generation | Cytotoxicity,Steatosis |
| Chlorpromazine |  | dopamine, serotonin, adrenergic, histamine receptors | Cholestasis,Cytotoxicity |
| Dimethoxy-naphthoquinone (DMNQ) |  | MOA standard for redox cycling | Cytotoxicity |
| Dirlotapide |  | MTTP inhibitor | Steatosis |
| FCCP |  | Cytotoxicity | |
| Fluoxetine |  | Selective serotinin reuptake inhibitor (SSRI),NMDA receptors containing the GluN2B | Phospholipidosis |
| Iodoacetamide |  | MOA standard for thiol alkylation | Cytotoxicity |
| Methotrexate |  | Dihydrofolate reductase (DHFR) inhibition | Fibrosis |
| Oligomycin A |  | ||
| Rifampicin |  | PXR receptor | Steatosis |
| Rotenone |  | complex I/ubiquinone | Cytotoxicity |
| TO901317 |  | ||
| Tamoxifen |  | estrogen receptor | Cholestasis,Epigenetics,Steatosis |
| Valproic Acid |  | GABA transaminase | Cytotoxicity |
