HepatotoxicCompounds
From ToxBankWiki
HepatotoxicCompounds
Gold Standard Hepatotoxic Compounds
The Gold Compound working group has accepted 20 and rejected 16 out of a total of 36 hepatotoxic compounds, based on Selection Criteria defined by the Gold Compound Working Group.
Accepted
Compound | Image | Target | Toxicities |
---|---|---|---|
Acetaminophen | ![]() | COX-2c | Cytotoxicity |
Aflatoxin B1 | ![]() | possibly DNA binding | Apoptosis |
Allyl alcohol | ![]() | Cytotoxicity,Fibrosis | |
Amiodarone | ![]() | beta blocker, K channel blocker | Cytotoxicity,Phospholipidosis,Steatosis |
Beta-Naphthoflavone | ![]() | ||
Bosentan | ![]() | endothelin receptor antagonist | Cholestasis |
CCl4 | ![]() | MOA standard for free radical generation | Cytotoxicity,Steatosis |
Chlorpromazine | ![]() | dopamine, serotonin, adrenergic, histamine receptors | Cholestasis,Cytotoxicity |
Dimethoxy-naphthoquinone (DMNQ) | ![]() | MOA standard for redox cycling | Cytotoxicity |
Dirlotapide | ![]() | MTTP inhibitor | Steatosis |
FCCP | ![]() | Cytotoxicity | |
Fluoxetine | ![]() | Selective serotinin reuptake inhibitor (SSRI),NMDA receptors containing the GluN2B | Phospholipidosis |
Iodoacetamide | ![]() | MOA standard for thiol alkylation | Cytotoxicity |
Methotrexate | ![]() | Dihydrofolate reductase (DHFR) inhibition | Fibrosis |
Oligomycin A | ![]() | ||
Rifampicin | ![]() | PXR receptor | Steatosis |
Rotenone | ![]() | complex I/ubiquinone | Cytotoxicity |
TO901317 | ![]() | ||
Tamoxifen | ![]() | estrogen receptor | Cholestasis,Epigenetics,Steatosis |
Valproic Acid | ![]() | GABA transaminase | Cytotoxicity |