Executive Summary Information
|Toxicities||Cytotoxicity with fibrosis|
|Mechanisms||Allyl alcohol is oxidized to acrolein by alcohol dehydrogenase, primarily in the liver. Acrolein is a potent alkylating reagent that is selective for glutathione and protein cysteines.|
|Comments||Allyl alcohol was selected as a compound with a relatively well-defined alkylating MOA that causes fibrosis. SAFETY CAUTION: allyl alcohol is a lachrymator, is readily absorbed through the skin, and can cause chemical burns to exposed organs, including eyes, lungs, and skin.|
|Feedback Contact||Gold Compound Working Group (GCWG)|
- In Vivo Data
- LIINTOP Data
- PK-ADME Data
- 'Omics and IC50 Data
- Physical Properties
- Recommended Product and Source
Human Adverse Events
The following data table has been mined from the Adverse Events Reporting System (AERS) of the US FDA. Significant human liver events. The first column ("# Reports") is the number of reports found for the corresponding adverse event reported in the third column ("Adverse Event"). The second column ("Report:Baseline Ratio") is ratio calculated from the number of reports ("# Reports") divided by a calculated expected statistical baseline number of reports.
|# Reports||Report:Baseline Ratio||Adverse Event|
|1||8.64492||bile duct necrosis|
|27||9.73229||venoocclusive liver disease|
The following resource link will perform a PubMed query for the terms "Allyl alcohol" and "liver toxicity".
Allyl alcohol Search
The table listed below contains a summarized listing of toxic effect information leveraged from the 6th European Framework Programme project LIINTOP. For a complete listing of the Gold Compound evaluation criteria please see the Gold Compound Evaluation and Comments immediately following the summary table below.
|Summary Hepatotoxic Effects from the LIINTOP FP6 Program|
- ↑ Feldmann, G., 2006. Liver apoptosis. Gastroenterol. Clin. Biol. 30, 533–545.
- ↑ Gomez-Lechon, M.J., O’Connor, E., Castell, J.V., Jover, R., 2002. Sensitive markers used to identify compounds that trigger apoptosis in cultured hepatocytes. Toxicol. Sci. 65, 299–308.
- ↑ Gomez-Lechon, M.J., O’Connor, J.E., Lahoz, A., Castell, J.V., Donato, M.T., 2008. Identification of apoptotic drugs: multiparametric evaluation in cultured hepatocytes. Curr. Med. Chem. 15, 2071–2085.
- ↑ Gomez-Lechon, M.J., Ponsoda, X., O’Connor, E., Donato, T., Jover, R., Castell, J.V., 2003. Diclofenac induces apoptosis in hepatocytes. Toxicol. in Vitro 17, 675– 680.
- ↑ Kass, G.E., Macanas-Pirard, P., Lee, P.C., Hinton, R.H., 2003. The role of apoptosis in acetaminophen-induced injury. Ann. NY Acad. Sci. 1010, 557–559.
The recommended source is Sigma Aldrich, product number 240532.
|Storage||Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Handle and store under inert gas.|