CCl4
From ToxBankWiki
Executive Summary Information
Compound | Carbon tetrachloride |
Toxicities | Steatosis, cytotoxicity |
Mechanisms | Carbon tetrachloride is oxidized to the trichloromethyl free radical, from which ensues alkylation of proteins and DNA along with lipid peroxidation. Depletion of ATP precedes acute cytotoxicity. Carcinogenicity is observed on long-term, low dose exposure. |
Comments | This compound was selected to exemplify free radical-based chemical reactivity and has secondary utility as a standard for steatosis and fibrosis. Acute toxicity due to a solvent effect on cellular membranes can complicate toxicity profiling, especially at concentrations above 0.5 mM. |
Feedback Contact | Gold Compound Working Group (GCWG) |
CCl4 | |
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Identifiers | |
Leadscope Id | LS-1373 |
CAS | 56-23-5 |
ChemSpider | 5730 |
UNII | CL2T97X0V0 |
ChEBI | 27385 |
Pathway DBs | |
KEGG | C07561 |
Assay DBs | |
PubChem CID | 5943 |
ChEMBL | 44814 |
Omics DBs | |
Open TG-Gate | 00003 |
Properties | |
ToxCast Accepted | yes |
ToxBank Accepted | yes |
Target | MOA standard for free radical generation |
Toxicities | Cytotoxicity,Steatosis |
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PubMed references
The following resource link will perform a PubMed query for the terms "carbon tetrachloride" and "liver toxicity".
Carbon tetrachloride Search
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The recommended source is Sigma Aldrich, product number 02671.
Tetrachloromethane (carbon tetrachloride) | |
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Source | Sigma Aldrich |
Product ID | 02671 |
Mol Weight | 153.82 |
Purity | ≥99.95 % |
Brand | Fluka-Analytical standard |
Quantity | 1 ml |
Cost | 19.8 |
Storage | Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Store in cool place. |
Stability | Limited shelf life, expiry date on the label |