Deoxycholate
From ToxBankWiki
Deoxycholate | |
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Identifiers | |
Leadscope Id | LS-53044 |
CAS | 83-44-3 |
ChemSpider | 193196 |
UNII | 005990WHZZ |
Pathway DBs | |
Assay DBs | |
PubChem CID | 222528 |
Omics DBs | |
Properties | |
ToxCast Accepted | no |
Toxic Effect | Apoptosis |
ToxBank Accepted | no |
Target | steroid, bile acid |
Executive Summary
Summary Information
The table listed below contains a summarized listing of toxic effect information leveraged from the 6th European Framework Programme project LIINTOP. For a complete listing of the Gold Compound evaluation criteria please see the Gold Compound Evaluation and Comments immediately following the summary table below.
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Summary Hepatotoxic Effects from the LIINTOP FP6 Program | |||||||||||||||||||||||
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The following table is organized into four main sections and provides a detailed assessment by the Gold Compound Working Group for the use of this compound as a standard hepatotoxin. The table's four sections (collapsed by default but will expand when the "show" link is clicked) contains detailed information for the core set of SEURAT compound acceptance criteria.
Standard to Meet | Compound Assessment | ||||||||||||||||||
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Proprietary Toxicity Literature Report
The toxicity literature report contains proprietary information and references for studies performed on this compound relevant to liver toxicity findings and is restricted for use within the SEURAT program only.
PubMed references
The following resource link will perform a PubMed query for the terms "Deoxycholate" and "liver toxicity".
Deoxycholate Search
References
- ↑ Feldmann, G., 2006. Liver apoptosis. Gastroenterol. Clin. Biol. 30, 533–545.
- ↑ Gomez-Lechon, M.J., O’Connor, E., Castell, J.V., Jover, R., 2002. Sensitive markers used to identify compounds that trigger apoptosis in cultured hepatocytes. Toxicol. Sci. 65, 299–308.
- ↑ Gomez-Lechon, M.J., O’Connor, J.E., Lahoz, A., Castell, J.V., Donato, M.T., 2008. Identification of apoptotic drugs: multiparametric evaluation in cultured hepatocytes. Curr. Med. Chem. 15, 2071–2085.
- ↑ Gomez-Lechon, M.J., Ponsoda, X., O’Connor, E., Donato, T., Jover, R., Castell, J.V., 2003. Diclofenac induces apoptosis in hepatocytes. Toxicol. in Vitro 17, 675– 680.
- ↑ Kass, G.E., Macanas-Pirard, P., Lee, P.C., Hinton, R.H., 2003. The role of apoptosis in acetaminophen-induced injury. Ann. NY Acad. Sci. 1010, 557–559.
Calculated/Predicted Properties
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Accepted by ToxBank | no + |
Accepted by ToxCast | no + |
Equivalent URIThis property is a special property in this wiki. | http://bio2rdf.org/cas:83-44-3 +, http://www.chemspider.com/Chemical-Structure.193196.rdf +, http://bio2rdf.org/pubchem:222528 +, and http://rdf.openmolecules.net/?InChI=1S/C24H40O4.Na/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3;/h14-21,25-26H,4-13H2,1-3H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-;/m1./s1 + |
Has CAS | 83-44-3 + |
Has ChemSpider Id | 193196 + |
Has InChI | InChI=1S/C24H40O4.Na/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3;/h14-21,25-26H,4-13H2,1-3H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-;/m1./s1 + |
Has InChIKey | FHHPUSMSKHSNKW-SMOYURAASA-M + |
Has Leadscope Id | LS-53044 + |
Has PubChem CID | 222528 + |
Has Smiles | O1C(O[C@@H]([C@@H]1Cl)Cl)(F)F + |
Has category | Hepatotoxic + |
Has image | Deoxycholate.png + |
Has target | steroid, bile acid + |
Has toxic effect | Apoptosis + |