| Series GSE2303
Title Rat liver response to Clofibrate, DEHP or VPA Organism(s) Rattus norvegicus.
Summary The project had 2 goals:
1) To evaluate the transcriptional response of 3 prototypical toxicants (Clofibrate, VPA, and DEHP) on rat lever.
2) To evaluate the impact pooling samples has on data analysis.
Jolly RA, Goldstein KM, Wei T, Gao H et al. Pooling samples within microarray studies: a comparative analysis of rat liver transcription response to prototypical toxicants. Physiol Genomics 2005 Aug 11;22(3):346-55
Title Classification of a large micro-array dataset. Algorithm comparison and analysis of drug signatures.
Organism(s) Rattus norvegicus
Natsoulis G, El Ghaoui L, Lanckriet GR, Tolley AM et al. Classification of a large microarray data set: algorithm comparison and analysis of drug signatures.
Genome Res 2005 May;15(5):724-36.
Toxicol Appl Pharmacol. 2008 Feb 1;226(3):271-84.
Subchronic effects of valproic acid on gene expression profiles for lipid metabolism in mouse liver.
Open TG-GATEs Human Liver
Status Public on Feb 25, 2011
Title Genomics Assisted Toxicity Evaluation system study - Human Hepatocytes
Organism(s) Homo Sapiens
Type Expression profiling by array
Summary TGP (Toxicogenomics project) is engaged by the Pharmaceutical Institute for Fundamental Research, National Institute of Health, and pharmaceutical companies (3) the public-private collaborative project. From FY 2002 through FY 2006 a large and high-quality Toxicogenomics database was built studying gene expression and toxicity information for 150 compounds in populations of rats and human hepatocytes exposed to drug.
Citation(s) Takeki Uehara, Atsushi Ono, Toshiyuki Maruyama, Ikuo Kato, Hiroshi Yamada, Yasuo Ohno, Tetsuro Urushidani. The Japanese toxicogenomics project: application of toxicogenomics.
Molecular nutrition & food research. 2010 Feb;54(2): 218-27