HepatotoxicCompounds
From ToxBankWiki
HepatotoxicCompounds
Gold Standard Hepatotoxic Compounds
The Gold Compound working group has accepted 20 and rejected 16 out of a total of 36 hepatotoxic compounds, based on Selection Criteria defined by the Gold Compound Working Group.
Accepted
Compound | Image | Target | Toxicities |
---|---|---|---|
Acetaminophen | COX-2c | Cytotoxicity | |
Aflatoxin B1 | possibly DNA binding | Apoptosis | |
Allyl alcohol | Cytotoxicity,Fibrosis | ||
Amiodarone | beta blocker, K channel blocker | Cytotoxicity,Phospholipidosis,Steatosis | |
Beta-Naphthoflavone | |||
Bosentan | endothelin receptor antagonist | Cholestasis | |
CCl4 | MOA standard for free radical generation | Cytotoxicity,Steatosis | |
Chlorpromazine | dopamine, serotonin, adrenergic, histamine receptors | Cholestasis,Cytotoxicity | |
Dimethoxy-naphthoquinone (DMNQ) | MOA standard for redox cycling | Cytotoxicity | |
Dirlotapide | MTTP inhibitor | Steatosis | |
FCCP | Cytotoxicity | ||
Fluoxetine | Selective serotinin reuptake inhibitor (SSRI),NMDA receptors containing the GluN2B | Phospholipidosis | |
Iodoacetamide | MOA standard for thiol alkylation | Cytotoxicity | |
Methotrexate | Dihydrofolate reductase (DHFR) inhibition | Fibrosis | |
Oligomycin A | |||
Rifampicin | PXR receptor | Steatosis | |
Rotenone | complex I/ubiquinone | Cytotoxicity | |
TO901317 | |||
Tamoxifen | estrogen receptor | Cholestasis,Epigenetics,Steatosis | |
Valproic Acid | GABA transaminase | Cytotoxicity |