Dirlotapide
From ToxBankWiki
Executive Summary Information
Compound | Dirlotapide (Slentrol) |
Toxicities | Steatosis |
Mechanisms | Dirlotapide is reversible Microsomal Triglyceride Transfer Protein (MTTP) inhibitor that blocks the assembly and release of lipoprotein particles from the liver into the blood. |
Comments | Dirlotapide was selected as a model compound to induce steatosis without accompanying chemical reactivity or promiscuous modulation of multiple proteins. |
Feedback Contact | Gold Compound Working Group (GCWG) |
Dirlotapide | |
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Identifiers | |
CAS | 481658-94-0 |
ChemSpider | 8093509 |
UNII | 578H0RMP25 |
Pathway DBs | |
KEGG | D03867 |
Assay DBs | |
PubChem CID | 9917862 |
ChEMBL | CHEMBL410414 |
Omics DBs | |
Properties | |
ToxCast Accepted | no |
ToxBank Accepted | yes |
Approved on | 2012-05-01 |
Target | MTTP inhibitor |
Toxicities | Steatosis |
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The recommended source for this product has not yet been determined.