FCCP
From ToxBankWiki
Executive Summary Information
Compound | FCCP (carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone) |
Toxicities | Cytotoxicity |
Mechanisms | FCCP is a protonophore that depletes the proton gradient of the mitochondrial membrane and uncouples respiration from ATP synthesis. FCCP is preferred as more specific in its activity compared to the common reagent, 2,4-dinitrophenol. |
Comments | This compound is an MOA standard for inhibition of mitochondrial function. |
Feedback Contact | Gold Compound Working Group (GCWG) |
FCCP | |
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Identifiers | |
Leadscope Id | LS-52242 |
CAS | 370-86-5 |
ChemSpider | 3213 |
Pathway DBs | |
Assay DBs | |
PubChem CID | 3330 |
Omics DBs | |
Properties | |
ToxCast Accepted | no |
Toxic Effect | Cytotoxicity |
ToxBank Accepted | yes |
Approved on | 20121023 |
Toxicities | Cytotoxicity |
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PubMed references
The following resource link will perform a PubMed query for the terms "FCCP" and "mytochondrial function".
FCCP Search
References
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