Dimethoxy-naphthoquinone (DMNQ)
From ToxBankWiki
Executive Summary Information
Compound | DMNQ (2,3-dimethoxy-1,4-naphthoquinone) |
Toxicities | Cytotoxicity |
Mechanisms | DMNQ is an oxidizing quinone with no alkylating activity. It has a relatively low reduction potential so that it can undergo redox cycling reactions. It depletes the cellular reduction potential, cause oxidation of proteins and DNA, and results ultimately in cell death. |
Comments | DMNQ is selected based on its chemical reactivity, representing quinones with low reduction potentials and without accompanying alkylating activity. This reactivity similar to that for doxorubicin but without affinity for DNA. |
Feedback Contact | Gold Compound Working Group (GCWG) |
Dimethoxy-naphthoquinone (DMNQ) | |
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Identifiers | |
Leadscope Id | LS-213329 |
CAS | 6956-96-3 |
ChemSpider | 3024 |
Pathway DBs | |
Assay DBs | |
PubChem CID | 3136 |
ChEMBL | 402468 |
Omics DBs | |
Properties | |
ToxCast Accepted | no |
ToxBank Accepted | yes |
Target | MOA standard for redox cycling |
Toxicities | Cytotoxicity |
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PubMed references
The following resource link will perform a PubMed query for the terms " Dimethoxy-naphthoquinone (DMNQ) " and "liver toxicity".
Dimethoxy-naphthoquinone (DMNQ) Search
The following resource link will perform a PubMed query for the terms " Dimethoxy-naphthoquinone (DMNQ) " and "cardio toxicity".
Dimethoxy-naphthoquinone (DMNQ) Search
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