Executive Summary Information
|Mechanisms||Binds to the 40S subunit of the 80S ribosome, distorting the ribosomal structure. The compound is generically toxic to all cell types in all species, including bacteria, fungi, and higher eukaryotes.|
|Comments|| This compound was selected for the validation of electron cryomicroscopy methods and is optional for more general profiling.
SAFETY WARNING: The powder is highly allergenic, is a lachrymator, and can be fatal if absorbed through the skin. Avoid contact or inhalation. The ears are especially sensitive to this reagent. It is preferable to handle this compound in aqueous solution. Reference
|Feedback Contact||Gold Compound Working Group (GCWG)|
The following resource link will perform a PubMed query for the terms "hygromycin b" and "liver toxicity".
Hygromycin B Search
The recommended source is Invivogen, product number ant-hg-10p.
|Comment||Price depending on local distributors, the reported price is from the italian distributor.|
|Storage||Store at -20 °C|
|Stability||Hygromycin is stable for at least one year at -20 °C, three months at room temperature, and at least one month at 37 °C. Hygromycin B is sensitive to high concentrations of acid, but short-term exposure to dilute acids can be tolerated.|